Home ageofautism Sleeping Sickness Drug is Waking Up Autism Research

Sleeping Sickness Drug is Waking Up Autism Research

Brain colorsBy Teresa Conrick

For any who don´t know, I have a 24 year-old daughter who regressed into autism before her 3rd birthday.  Meg has the type of autism that does not make for an easy life.  She lost speech in 1995 and she is nonverbal still, and waves of difficult and painful medical symptoms then were to follow: cognitive decline, increasing GI issues, chronic bacterial infections and viral illnesses, seizures, and then a horrific autoimmune disorder called PANS [Pediatric Autoimmune Neuropsychiatric Syndrome] .

For years now, I have been following the research on the Microbiome as there are solid studies showing how dysfunctional it is in those with an autism diagnosis.  Studies like these represent hope for many families with very ill children and young adults:

Reduction of Ritualistic Behavior in a Patient with Autism Spectrum Disorder treated with Antibiotics: A Case Report 

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study  

Combined oral fecal capsules plus fecal enema as treatment of late onset autism spectrum disorder in children: report of a small case series. 

Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics 

Age and severity may play a part in outcomes with our children as far as treatments.  I have now been following the research of Dr. Naviaux, still with the microbiome in mind, but also with a better understanding of its significance.  It seems that his research explains much of what I see in Meg, especially with the issues of the gut and brain.  You can watch this great video of a lecture by Dr. Naviaux, at a very recent TACA conference.  Thanks to them both!     

And in that lecture, Dr. Naviaux recommends that viewers read his study called, Metabolic features of the cell danger response  http://www.sciencedirect.com/science/article/pii/S1567724913002390.  Here are some excerpts:

The cell danger response (CDR) is an evolutionarily conserved cellular metabolic response that is activated when a cell encounters a chemical, physical, or microbial threat that could injure or kill the cell. Common microbial threats are viruses, bacteria, fungi, and parasites. Physical threats include heat, salt, or pH shock, or UV or ionizing radiation. Chemical forms of danger include heavy and trace metals like lead, mercury, cadmium, arsenic, and nickel, certain electrophilic aromatic chemicals like the plasticizer bisphenol A, the chemical flame retardants like the brominated diphenyl ethers (BDEs), and certain halogenated pesticides like chlorpyrifos and DDT. 

Age Of Autism

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